STAT3 and acute promyelocytic leukemia: In addition, ATI enhanced the level of Aquaglycoporin 9, promoted the transport of a to APL cells, and then promoted the degradation and therapeutic effect of PML-RARα mediated by A. In the cell viability and induce apoptosis test of 2 human ovarian cancer cell lines, indirubin can inhibit cell activity and induce apoptosis with dose dependence by downregulating the phosphorylation of STAT3 (tyr705), and significantly suppressing the expression of cyclin D1 and c-myc downstream of STAT3 [31].