When the microbial communities’ functional composition was compared between CRC-bearing mice and control (Fig. 4e and Supplementary Table S3), according to the level 2 KEGG module the relative abundance of immune system diseases (FDR = 0.012) category together with carbohydrate metabolism (FDR = 0.015) [41] emerged significantly higher in xenogeneic BRAF-mutated CRCs, whereas a remarkable enrichment of general metabolic functions was observed in BRAF wt CRCs. Here, BRAF is linked to immune system disorder.