As indicated by the a-diversity Shannon index, xenogeneic BRAF-mutated CRC and controls displayed a higher microbial community diversity than BRAF wt CRC-carrier group, both at genus and species level (P < 0.0001 and P = 0.004, respectively, Kruskal-Wallis test) (Fig. 3b, top), whereas genus and species richness did not reach significance among the groups (Fig. 3b, middle and bottom). Here, BRAF is linked to colorectal carcinoma.