At the beginning, Cobas 4800 BRAF V600 Mutation Test (Roche Molecular Systems) and THxIDTM-BRAF kit (BioMerieux, Inc.)were the only FDA-approved assays for BRAF V600E mutation and for BRAF V600E/V600K mutations in DNA samples extracted from Formalin-Fixed Paraffin-Embedded (FFPE) human melanoma tissue, respectively (http://www.fda.gov/companiondiagnostics) [25–27]. Here, BRAF is linked to melanoma.