In case of a BRAF-wild type tumor, NRAS and c-KIT (mucosal and acrolentigenous primaries) testing should be performed (Italian Association of Medical Oncology/AIOM Guidelines Melanoma - 2019, available at: https://www.aiom.it/linee-guida-aiom-melanoma-2019/; National Comprehensive Cancer Network/NCCN clinical practice guidelines in oncology: melanoma - 2019, available at: https://www.nccn.org/professionals/physician_gls/pdf/cutaneous_melanoma.pdf) [7]. This evidence concerns the gene BRAF and melanoma.