BTK and diffuse large B-cell lymphoma: Furthermore, BTK inhibition may synergize with immunotherapy, since acalabrutinib in combination with pembrolizumab resulted in ORRs of 27% in GCB (n = 30) and 26% in non-GCB r/r DLBCL (n = 31), with a median DoR of 6.9 months [97].