Aberrant expression and genetic disorders of CD79b, CARD11, MYD88, TNFAIP3, BCL-10, TRAF3, TRAF2, NFKBIA, and NFKBIE (IkBε), in concordance with the prevalence of chronic-active B cell receptor (BCR) signaling, JAK-STAT3 signaling, and canonical NF-κB signaling, were believed to underlie the inferior outcomes of ABC DLBCL (Fig. 4) [85]. The gene discussed is NFKBIE; the disease is diffuse large B-cell lymphoma.