Using IDH-WT GBM-derived TSs, we found a positive association between the levels of TERT and TP53. Furthermore, GBM tissues also displayed this association (Fig. 1) [58, 61], and other publicly available data suggest that TERT and TP53 are associated in other tumor types and normal brain tissue, such as lower grade glioma, head and neck cancer, and acute myeloid leukemia [58]. Here, IDH1 is linked to acute myeloid leukemia.