The expression pattern and response to TMZ of IGFBP5, which is commonly upregulated in GBM than cortical tissues, may need attention as it has been studied as one of important factors of GBM and gliomas (Fig. 6b). About the association between TP53 and NEAT1 (Additional file 10), we need more evidences whether they are correlated in biological manner. This evidence concerns the gene NEAT1 and central nervous system cancer.