Given that the functional effects of m6A methylation are dependent on the m6A reader proteins of the YTH domain family, we screened the Oncomine database to study the expression of five members of this family in multiple GBM datasets, and found that one of them, YTHDF1, was the most highly upregulated in GBM as compared to the normal tissues (Fig. 1a). The gene discussed is YTHDF1; the disease is glioblastoma.