As part of these efforts, we also utilized XMAS-TREE to enrich for cells that have been edited at several disease-relevant loci including those associated with sickle-cell anemia (i.e., HBG1, HBG2) and Alzheimer’s disease (i.e., AKAP9, PSEN1) [28, 29, 31]. Here, AKAP9 is linked to early-onset autosomal dominant Alzheimer disease.