In the multivariate survival analysis using a Cox proportional hazards model, high pre-NACRT mGPS (2 or 1; p = 0.0478), significant increase in CRP/Alb ratio (high ΔCRP/Alb) after NACRT (≧ 0.077; p = 0.0036), lymph node metastasis (N1 or N2; p = 0.0117), and positive surgical margin (R1; p = 0.0295) were associated with shorter OS, with statistical differences (Table 2). The gene discussed is CRP; the disease is metastatic malignant neoplasm in the lymph nodes.