In this regard, a recent HiChIP study that combined the detection of H3K27ac and cohesin subunit Smc1 HiChIP in T-cells of T1D mice model showed hyperconnected 3D clusters in T1D-associated regions, including important genes in autoimmunity such as BCL11B and ETS1, whereas these hyperconnected clusters were not present in T-cells from diabetes-resistant mice [84]. Here, SMC1A is linked to type 1 diabetes mellitus.