For example, the A353V mutation in the DKC1 gene, which is the most common mutation in X linked dyskeratosis congenita (X-DC) patients, causes a reduction in the levels of hTERC RNA [46], while another report revealed that loss of dyskerin caused degradation of hTERC in vivo [47]. This evidence concerns the gene DKC1 and dyskeratosis congenita, X-linked.