An in vitro study utilising skin biopsies from patients with hEDS and hypermobility spectrum disorder (HSD) has identified a possible signalling pathway (αvβ3-ILK-Snail1/Slug axis) which promotes the transition of fibroblasts to myofibroblasts in hEDS and HSD patients, which was absent in biopsies from patients with classical EDS and vascular EDS [21]. This evidence concerns the gene ILK and Ehlers-Danlos syndrome, hypermobility type.