A series of studies suggested that FGF-21 exhibits diverse beneficial functions against myocardial infarction and adverse cardiac remodeling, while elevated circulating FGF-21 is also suggested to be a sensitive biomarker for the detection of I/R injury during liver transplantation [120], implying that elevation of blood FGF-21 might be considered as an endogenous adaptive response against cellular damage. This evidence concerns the gene FGF21 and myocardial infarction.