CDX2 and Cowden syndrome 1: For example, IPNBs with liver fluke infection, particularly Clonorchiasis sinensi (CS), tended to have a more pancreatobiliary phenotype (MUC1+/MUC2-/CDX2-) [142,143], whereas IPNBs negative for CS were characterized by the intestinal phenotype (MUC2+/CK20+) [143].