APC and pancreatic intraductal papillary-mucinous neoplasm: Given these previous findings, the activation of the Wnt/β-catenin signaling pathway associated with APC and CTNBB1 mutation may be involved in the development and progression of non-intestinal-type IPNBs, particularly the pancreatobiliary subtype [130,137], and the genetic alterations of this type differ from those seen with IPMN [130,136].