Ohtsuka et al. [31,96] also reported that mucin-hypersecreting IPNBs showed striking similarities to IPMN and were usually in situ carcinoma or minimally invasive, whereas IPNBs without mucin hypersecretion were frequently associated with invasive carcinoma. The gene discussed is MUC5AC; the disease is pancreatic intraductal papillary-mucinous neoplasm.