TLR8 and Parkinson disease: The auto-aggressive process of autoimmune PD may be enhanced by a triggered activation of microglia, resulting in an amplification of the adaptive immune response against NM and/or α-syn and the local reactivation of immigrating effector T cells [2]; we found that the simultaneous genetic deletion of TLR7 and TLR8 in mice significantly reduced astrogliosis and microgliosis induced in PD.