VEGFA and central nervous system cancer: EV-derived HOTAIR has also been shown to play a role in angiogenesis in neuroblastoma, where glioma cells shuttle it to endothelial cells to induce Vascular Endothelial Growth Factor A (VEGFA) expression [147] and silencing of HOTAIR-inhibited glioma-induced endothelial cell proliferation, migration, and tube formation [147].