In triple-negative breast cancer cells, miR-939 and miR-105 are packaged in EVs, where they target vascular endothelial cadherin (VE-cadherin) and Zonula occludens-1 (ZO-1), respectively, once up taken by endothelial cells, resulting in the disruption of the endothelial barrier and increased permeability [133,134]. Here, CDH5 is linked to triple-negative breast carcinoma.