H520 cells, like H1581 cells, are characterized by FGFR1 amplification and autocrine FGF stimulation (Table S1) [19], whereas HCC827 cells are adenocarcinoma cells that harbor a tumor driving mutation in the TK domain of EGFR which makes these cells independent from the FGF/FGFR system, notwithstanding their FGF/FGFR expression (Table S1) [25]. Here, FGFR1 is linked to adenocarcinoma.