However, Fukazawa et al. [168] demonstrated that caspase-3 activation induced by cis-diamminedichloroplatinum treatment under simulated microgravity was independent of the p53 status in HepG2 hepatoblastoma cells, suggesting that enhanced apoptosis signaling under simulated microgravity conditions may be regulated through signals other than those transmitted by p53. This evidence concerns the gene TP53 and hepatoblastoma.