The loss of interplay between CD200-CD200R will induce microglial proliferation and activation that may exacerbate the process of neuroinflammation and aggravate the prognosis after stroke, as has been shown in a recent study conducted on CD200R1 knock-out mice, in which more deaths took place commensurate to the group of wild-type mice, probably because this induces monocyte infiltration and microgliosis [20]. The gene discussed is CD200; the disease is stroke disorder.