IFNG and cancer: Interestingly, and potentially more relevant to hepatic NK cell targeting of cancer cells, the parenchymal CD56BrightCD49a+EomesNegT-betHi subset of lr-Nk cells express MHC class I specific receptors (KIR, NKG2C) and are able to efficiently produce high levels of pro-inflammatory cytokines (IFN-γ, TNF and GM-CSF) [167].