BAP1 and uveal melanoma: Subsequent chromosomal and genetic alterations broadly divide uveal melanoma into three metastatic-risk groups: (1) High-risk: Characterized by loss of one copy of chromosome 3 (Monosomy 3), gain of chromosome 8q and BRCA Associated Protein-1 (BAP-1) gene mutation leading to a loss of BAP-1 expression [11,12,13,14]; (2) Medium risk: Involving disomy 3, gain of chromosome 6p and SF3B1 or SRSF2 mutations [15,16,17]; (3) Low-risk: Involving disomy 3, gain of chromosome 6p and EIF1AX mutation [18,19].