Indeed, insulin roles within both adipocytes and bone stromal stem cells of the bone marrow [45] suggest an impact of increased insulin on both regeneration and metabolism, as illustrated by the obesity-associated hypermetabolism leading to bone fragility [46], especially with the important roles that marrow adipocytes play in bone homeostasis [47] and remodeling [48]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.