A poly (ethylene glycol) (starPEG)–heparin hydrogel scaffold was used to grow leukemia lines, KG1a, MOLM13, MV4-11, and OCI-AML3, and primary cells from AMLs, HUVCEs, and MSC to mimic cell interactions between AML and the vascular niche [58]. This evidence concerns the gene RUNX2 and acute myeloid leukemia.