For instance, Mucin 1 (MUC1) acts as an ERα coactivator by stabilizing its binding to ERE promoters and by recruiting histone acetyl-transferases of the p160 family to promote ERα-induced gene transcription [66]; consistently, MUC1-knock down in HR+ BC cells is associated with reduced ERα levels [61]. The gene discussed is ESR1; the disease is breast cancer.