PLIN1 and obesity due to melanocortin 4 receptor deficiency: In a model of murine obesity, it was described that the production of circulating EVs is increased during obesity and correlated to glucose intolerance and macrophage infiltration in AT; and more interestingly, the authors describe perilipin A (perilipin-1) as an adipose tissue EV biomarker that can be detected by immunoblot at circulating level.