STAT1 and colorectal carcinoma: In a set of 64 UMs, the expression of HDACs 1, 4, and 8 was positively correlated with the expression of HLA Class I. Using malignant cell lines such as from colorectal carcinoma, e.g., HDAC1 has been shown to be related to inflammation, by inducing STAT1 activation and the transcription of downstream targets of the IFN-Ƴ signalling pathway [35,36]; such targets include HLA Class I components.