The observed upregulation of PDK1 and PDK3 in basal-like breast cancers and their correlation with a hypoxic phenotype (which is linked to the activation of a HIF1α−dependent transcriptional program), suggests that the use of PDK inhibitors could serve as an attractive therapeutic modality for hypoxic radiosensitization purposes [42,43,44]. Here, PDK1 is linked to breast carcinoma.