TP53 and neoplasm: Furthermore, the expression of the up-regulated selected apoptosis-related gene TP53 related to TZ-treated animals was confirmed by the results of Aubrey et al. [46], who discuss the mechanisms by which P53-induced cell death occurs and how this affects P53-mediated tumor suppression genes and the malignant cells response during the anticancer therapy, as shown in the following Figure 4 and facts about P53.