There is also controversy regarding CHC, leptin and gender, BMI and age; while some papers showed a positive relation between serum leptin levels and female gender [240,242,250], BMI [242,244,245], and age [240,242], others manifested no relation between serum leptin levels and these parameters in steatotic patients [244], genotype 3 infected patients [242] or cirrhotic patients [245]. Here, LEP is linked to cryohydrocytosis.