In vitro, it has been demonstrated that leptin induces the proliferation of hepatoma cells via stimulation of DNA synthesis and enhancement of mitotic activity [171] and also promotes hepatome cell invasion and migration via a signaling pathway that involves JAK/STAT, ERK, and PI3K/AKT, as it has been already mentioned throughout this manuscript [172];, but it also has a critical role in the hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase [13]. Here, LEP is linked to hepatocellular carcinoma.