Carmina et al. [50] observed that LEP expression decreases with increasing body mass index both in the omentum and in the subcutaneous fat, while Viesti et al. [51] did not detect a significant difference in LEP expression in the omentum and liver of the obese subjects compared tocontrol.Obesity is related to several skin diseases in the human species including poor wound healing and increased risk of dermatitis, such as psoriasis [25]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.