Inversely, hypertensive carriers of the CC genotype of rs2277869 (WNK1) showed increased ambulatory blood pressure as compared to carriers of CT and TT genotypes [8], whereas genotypes (CC and CT) of rs2107614 of the WNK1 gene were associated with a greater reduction in whole-day ambulatory blood pressure among patients with essential hypertension who were treated with HCTZ [8]. This evidence concerns the gene WNK1 and essential hypertension.