ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive: Because they carry the chromosomal abnormality present in ~95% of CML patients, EVs themselves could serve as an alternative early diagnostic marker for detection of Ph1+ CML instead of the labor-intensive conventional fluorescent in situ hybridization technique performed on bone marrow aspirates to detect BCR/ABL translocation [46,47].