Meanwhile, we also evaluated the influence of FX5 on the protein levels of G6Pase and PEPCK in the liver tissues of T2DM mice by western blot, and the results demonstrated that FX5 treatment (Figure 6C, 6D for db/db T2DM mice, Figure 6G, 6H for HFD/STZ induced T2DM) decreased the protein levels of these two gluconeogenesis genes. Here, PCK2 is linked to type 2 diabetes mellitus.