NR3C1 and type 2 diabetes mellitus: Additionally, considering that 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) expression is increased in T2DM [12] and 11β-HSD1 converts inactive 11-dehydrocorticosterone into bio-active corticosterone thus amplifying GR signaling in hepatocytes [37, 38], we investigated the potential impact of FX5 on 11β-HSD1.