In case of the MSI-L/MSS subgroup, the significantly de-regulated gene PTH1R a member of the GPCR family of proteins, is defined as a type 1 parathyroid hormone receptor [21], which serves as an oncogene in breast cancer as silencing of PTH1R suppressed cell proliferation and induced apoptosis in breast cancer cells [22]. This evidence concerns the gene PTH1R and breast carcinoma.