Silent mating-type information regulation 2 homolog 1 (SIRT1, sirtuin 1), a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase, has been implicated in a variety of physiological processes, including senescence, obesity, and inflammation [19, 20]. This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.