Consistent with previous oncologic studies about B3GNT3, multiple PC databases indicated that B3GNT3 was notably overexpressed in tumor tissues [12, 16, 24], and positively correlated with tumor size, histologic grade, and poor survival of patients with PC, which indicates that B3GNT3 may be an unfavorable prognostic biomarker for PC. This evidence concerns the gene B3GNT3 and pachyonychia congenita.