The pathogenesis of acute kidney injury associated with covid-19 is multifactorial,but volume depletion on admission, secondary to fever and insensitive losses, can bea common trigger for AKI, since pre-hospital resuscitation with fluids is rarelyperformed, leading to a pre-renal AKI due to renal hypoperfusion.19 Rhabdomyolysis may also be associated withAKI, since critically ill patients commonly present significant elevations ofcreatinophosphokinase (CPK). The gene discussed is PIK3C2A; the disease is acute kidney injury.