Interestingly, it has been reported that the neurofilament genes NEFH, NEFL and NEFM, gene products that comprise the major cytoskeletal component of neurons, are frequently silenced via promoter methylation in a variety of cancers including breast, pancreas, gastric and colon and this gene inactivation is correlated with disease progression and adverse clinical parameters [19]. Here, NEFL is linked to cancer.