Hispanic CMML patients from Puerto Rico in our current study had lower mutation rates in ASXL1 and SETBP1, but a higher mutation rate of DNMT3A. DNMT3A mutation was reported to be associated with an unfavorable prognosis in CMML [23], the true clinical significance of DNMT3A mutation in Hispanic CMML patients and how DNMT3A interacts with other mutations are uncertain. The gene discussed is DNMT3A; the disease is chronic myelomonocytic leukemia.