Matthew et al. had generated an immunocompetent mouse model of ZIKV infection by introducing human STAT2 into the mouse Stat2 locus (hSTAT2 KI), subcutaneous inoculation of pregnant hSTAT2 KI mice with ZIKV-Dak-MA resulted in spread to the placenta and fetal brain [69]. The gene discussed is STAT2; the disease is Zika virus infectious disease.