MTHFR and folate deficiency: Given the increased demands for folate during pregnancy, and the impact of folate deficiency on TT homozygous women [26], there is need to further understand the role of MTHFR C677T and folate levels on postpartum psychopathology, especially since there has been some suggestion of using folic acid or L-methylfolate supplements to treat low mood in the postpartum and the general population in those with MTHFR C677T variants [27, 28].