ZMPSTE24 and Hutchinson-Gilford progeria syndrome: Mutations in LMNA or ZMPSTE24 that prevent prelamin A cleavage cause the severe premature aging disorder Hutchinson-Gilford Progeria syndrome (HGPS) or the related progeroid diseases, mandibuloacral dysplasia type-B (MAD-B) and restrictive dermopathy (RD) [8–15].