Therefore, it is speculated that predisposition of autoimmunity such as positivity for IF-ANA, SSA Ab, and dsDNA Ab are prone to generate ADrA such as HACA and AAA (immunogenicity), and that the relationship between autoimmunity and immunogenicity was prominent in IFX therapy because HACA production was closely associated with increased IF-ANA and dsDNA Ab titers from baseline. The gene discussed is BTG3; the disease is Autoimmunity.