As to the relationship of IF-ANA titers to ADrA appearance after IFX and ADA, the positive rate for HACA was significantly higher in the patients positive for IF-ANA titers of ≥320 and ≥640 after the therapy (P = 0.0022 and P = 0.0004, respectively); however, IF-ANA titers after ADA therapy were not related to AAA appearance (Fig 4). The gene discussed is ADA; the disease is triple-A syndrome.