The optimal cut-off value of serum PTX3 to discriminate sepsis from healthy individuals was 15.10 ng/mL (sensitivity, 92.6%; specificity, 97.4%; P < 0.001) and distinguish septic shock was 58.28 ng/mL (93.2% sensitivity, 60.7% specificity, P < 0.001). The gene discussed is PTX3; the disease is Sepsis.