In a metaanalysis for acute phase reactants related to COVID-19 revealed that elevated serum CRP was associated with an increased some poor outcome [RR 1.84 (1.45, 2.33), P < 0.001; I2: 96%, P < 0.001] like severity of disease or need for intensive care unit, but not mortality [14]. This evidence concerns the gene CRP and COVID-19.