Looking closer at the curves of primary GBM cells, the data revealed at both curves overlap at most data points except at 1 μM (~ 0.5 μg/mL) doxorubicin (red circle in Fig. 5c), which explains the difference in IC50 values and indicates that a potential synergism of MET and doxorubicin highly depends on cell line and applied drug concentrations. This evidence concerns the gene MET and glioblastoma.