Different formulations showed different sizes and zeta potentials. Importantly, silver NPs reduced cellular viability, increased IL8, and decreased IL10 mRNA expression when exposed to MDM. For the TB- infected MDM, silver NP suppressed. M. tb-induced expression of IL1β, IL10, and TNFα mRNA, and TB bacteria was inhibited by silver NPs. This evidence concerns the gene IL10 and tuberculosis.