MME and Alzheimer disease: Plenty of in vitro and in vivo experiments have demonstrated the activity of NEP as a key factor of AD (Fukami et al., 2002; Guan et al., 2009; Huttenrauch et al., 2015; Iwata et al., 2001; Kanemitsu et al., 2003; Liu et al., 2009, 2010).