While glutamine removal did not affect either GLS levels in Notch1‐positive T‐ALL cells (Fig. 5B), the levels of GLS (both at the RNA and protein level) were enhanced in NICD cells with respect to EV cells when these cells were incubated in all amino acid restricted conditions (Fig. 5C,D). This evidence concerns the gene NOTCH1 and acute lymphoblastic leukemia.