Indeed, although RAP treatment efficiently inhibited mTORC1 both in Notch1‐positive and Notch1‐negative T‐ALL cells (Figs 7D and S3g), it induced a further decrease of cell viability only in Notch1‐positive cells during glutamine‐restrictive conditions (Fig. 7E,F and S3h‐i). Here, NOTCH1 is linked to acute lymphoblastic leukemia.