Although some clinical studies have suggested that adenocarcinoma, nonsmoking status, female sex, and Asian race are predictors of EGFR mutations,7, 8, 9 studies have also shown that adenomatous hyperplasia, atypical adenomatous hyperplasia, adenocarcinoma in situ, and squamous dominant adenocarcinoma frequently carry EGFR mutations.10, 11, 12, 13, 14, 15. Here, EGFR is linked to adenocarcinoma in situ.