Tumor infiltration of adjacent organs and structures was associated with decreased survival (HR = 8.90, p = 0.007; Table 2), increased risk of INSS stage 4 disease (OR = 8.96, p < 0.001; Table 2), MYCN amplification (OR = 9.91, p = 0.001; Table 2), and high MKI (OR = 6.20, p = 0.003; Table 2). This evidence concerns the gene MYCN and neoplasm.