However, combination treatment with MK‐571 significantly enhanced APR‐246 anti‐tumor activity (Fig 2A, and Appendix Fig S2A and B) and survival (Fig 2B) in MRP1‐expressing Eso26 xenografts (Appendix Fig S2C), consistent with the in vitro data on esophageal cell lines (Fig EV1B). The gene discussed is ABCC1; the disease is neoplasm.