Four of seven differentially expressed genes identified in human GWAS studies, were tentatively reported as loci associated with human neurological diseases: Slc8a3 for bipolar disorder,41Pmvk for Parkinson's disease,42Kcnt2 and Dusp18 for Alzheimer's disease,43 and Kcnt2 for insomnia and chronotype traits.44, 45. Here, SLC8A3 is linked to early-onset autosomal dominant Alzheimer disease.